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Most chronic diseases of the CNS are associated with loss of function of astrocytes, and such loss of function is emerging as a leading mechanism of disorder-related neurological dysfunctions ranging from mild changes in synapse regulation to potential overt neurotoxicity in extreme cases

doi: 10.1111/j.1365-2672.2012.05344.x 166 ZhouHZhangSZhangXZhouHWenTWangJ

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Anselmo AC, Gokarn Y, Mitragotri S